Adherence to the atrial fibrillation better care pathway and its associated factors among rural patients with atrial fibrillation in China: A cross-sectional study.

BACKGROUND: The atrial fibrillation better care (ABC) pathway is an effective strategy for the integrated management of atrial fibrillation (AF). Current data on adherence to the ABC pathway among rural patients with AF in China are limited. OBJECTIVES: To investigated adherence to the ABC pathway and its associated factors among rural patients with AF in China. METHODS: In the cross-sectional study, we recruited 870 rural patients with AF from July 2022 to July 2023 in China. AF-related sociodemographic and clinical data was collected. RESULTS: Among the 870 rural patients with AF, 437 (50.23 %) were male, 714 (82.07 %) were ≥65 years old. The level of adherence to ABC pathway was extremely low (5.75 %), and its associated factors included patients ≥75 years (compared with those <65 years, OR=0.165, 95 %CI: 0.065-0.417, P < 0.001), junior middle school and senior middle school education or above (compared with primary school education or below, OR=3.441, 95 %CI: 1.144-10.351, P = 0.028; OR=11.438, 95 %CI: 3.758-34.814, P < 0.001), average monthly household income per capita 1000-3000 RMB and >3000 RMB (compared with <1000 RMB, OR=3.993, 95 %CI: 1.343-11.877, P = 0.013; OR=4.474, 95 %CI: 1.478-13.541, P = 0.008), persistent AF (compared with paroxysmal AF, OR=0.062, 95 %CI: 0.008-0.466, P = 0.007) and multimorbidity (OR=0.356, 95 %CI: 0.163-0.781, P = 0.010). CONCLUSIONS: There is an urgent need to develop targeted interventions and national policies to improve the adherence to the ABC pathway of rural AF patients in China.

[Extraction of three tanshinones from the root of Salvia miltiorrhiza Bunge by supercritical carbon dioxide fluid and their analysis with high performance liquid chromatography].

The extraction of three tanshinones from the root of Salvia miltiorrhiza Bunge by supercritical carbon dioxide (SC-CO2) fluid with ethanol as co-solvent was investigated using four-factor and three-level orthogonal design method and the systematic method. The optimized conditions were established as follows: 95% ethanol was selected as a co-solvent, flow rate of co-solvent was 1.0 mL/min, extraction pressure was 20 MPa, extraction temperature was 45 degrees C, separation temperature was 35 degrees C. The sample solution was separated on a Nova-Pak C18 column (3.9 mm i.d. x 300 mm, 5 microns) with CH3OH-H2O (80:20, V/V) as the mobile phase and detected at 280 nm. The correlation coefficients were 0.9994-0.9998 and the relative standard deviations were 2.37%-3.47%. The detection limits were 0.473 mg/L, 0.184 mg/L and 0.452 mg/L for tanshinone-II A, tanshinone-I and cryptotanshinone respectively.